Acetic Anhydride → N-acetyl-2-furfurylthioacetamide

HRID 52436ノート

反応式

HRID 52436 の反応式
[CH2:1]([CH2:7][C:8]([NH2:10])=[S:9])[C:2]1[O:6][CH:5]=[CH:4][CH:3]=1.[C:11](OC(=O)C)(=[O:13])[CH3:12].C(OCC)(=O)C>N1C=CC=CC=1>[C:11]([NH:10][C:8](=[S:9])[CH2:7][CH2:1][C:2]1[O:6][CH:5]=[CH:4][CH:3]=1)(=[O:13])[CH3:12]

参加物

5

反応物 3

HCID 7918Acetic AnhydrideHCID 8857Ethyl AcetateHCID 199636792-Furfurylthioacetamide

生成物 1

HCID 19963689N-acetyl-2-furfurylthioacetamide

試薬・触媒・溶媒 1

HCID 1049Pyridine溶媒

反応条件

温度
80 °C

実験手順

8.56 g (0.05 mol) of 2-furfurylthioacetamide, 5.61 g (0.055 mol) of acetic anhydride, and 6.11 g (0.05 mol) of N,N-dimethyl-aminopyridine were dissolved in 50 ml of pyridine. The mixture was stirred at 80° C. for 16 hours. The solvent was distilled away from the reaction mixture, and the residue thus obtained was added to ethyl acetate and washed successively with water, 1N hydrochloric acid, water three times, and brine. A resultant organic extract layer was dried, and the solvent was distilled away therefrom, so that N-acetyl-2-furfurylthioacetamide was obtained in a yield of 7.11 g (60%).

後処理

  1. distillationThe solvent was distilled away from the reaction mixture
  2. customthe residue thus obtained
  3. washwashed successively with water, 1N hydrochloric acid, water three times, and brine
  4. customA resultant organic extract layer was dried
  5. distillationthe solvent was distilled away

出典と根拠

ORDレコード
ord-76330c2324714914941aad18f42a0b71
出典データセット
uspto-grants-1997_04
特許番号
US05616711

反応ノート

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