Methanesulfonyl chloride → N-[4-(3-morpholin-4-yl-quinoxalin-6-yl)-phenyl]-methanesulfonamide

HRID 524376ノート

反応式

HRID 524376 の反応式
[N:1]1([C:7]2[CH:8]=[N:9][C:10]3[C:15]([N:16]=2)=[CH:14][C:13]([C:17]2[CH:22]=[CH:21][C:20]([NH2:23])=[CH:19][CH:18]=2)=[CH:12][CH:11]=3)[CH2:6][CH2:5][O:4][CH2:3][CH2:2]1.[CH3:24][S:25](Cl)(=[O:27])=[O:26]>N1C=CC=CC=1>[N:1]1([C:7]2[CH:8]=[N:9][C:10]3[C:15]([N:16]=2)=[CH:14][C:13]([C:17]2[CH:22]=[CH:21][C:20]([NH:23][S:25]([CH3:24])(=[O:27])=[O:26])=[CH:19][CH:18]=2)=[CH:12][CH:11]=3)[CH2:2][CH2:3][O:4][CH2:5][CH2:6]1

参加物

4

反応物 2

HCID 31297Methanesulfonyl chlorideHCID 670349784-(3-Morpholin-4-yl-quinoxalin-6-yl)-phenylamine

生成物 1

HCID 67035522N-[4-(3-morpholin-4-yl-quinoxalin-6-yl)-phenyl]-methanesulfonamide収率 56.6%

試薬・触媒・溶媒 1

HCID 1049Pyridine溶媒2 回

実験手順

A mixture of 4-(3-morpholin-4-yl-quinoxalin-6-yl)-phenylamine [intermediate example 4.1] (100 mg) and pyridine (0.5 mL) was treated with a solution of methane sulfonyl chloride (75 mg, 0.65 mmol) in pyridine (0.6 mL) and stirred at room temperature overnight. The reaction was partitioned between dichloromethane and water, the phases separated and the organic layer concentrated in vacuo. The residue was triturated with dichloromethane and filtered to give the title compound (71 mg). UPLC-MS: RT=0.97 min; m/z (ES+) 385.19 [MH+]; required MW=384.46.

後処理

  1. customThe reaction was partitioned between dichloromethane and water
  2. customthe phases separated
  3. concentrationthe organic layer concentrated in vacuo
  4. customThe residue was triturated with dichloromethane
  5. filtrationfiltered

出典と根拠

ORDレコード
ord-f7e53d73adde4720bcccd5ae72430ffb
出典データセット
uspto-grants-2016_05
特許番号
US09340528B2

反応ノート

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