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Isocyanatocyclopropane → 1-Cyclopropyl-3-[4-(3-morpholin-4-yl-quinoxalin-6-yl)-phenyl]-urea
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Isocyanatocyclopropane | HCID 637659 | — |
| 反応物 | 4-(3-Morpholin-4-yl-quinoxalin-6-yl)-phenylamine | HCID 67034978 | — |
| 溶媒 | Dichloromethane | HCID 6344 | — |
| 生成物 | 1-Cyclopropyl-3-[4-(3-morpholin-4-yl-quinoxalin-6-yl)-phenyl]-urea | HCID 67035245 | 75.5% |
反応手順
A mixture of 4-(3-morpholin-4-yl-quinoxalin-6-yl)-phenylamine [Intermediate Example 4.1] (100 mg) in dichloromethane (3.3 mL) was cooled (ice bath) and treated with cyclopropyl isocyanate (30 mg, 0.36 mmol) and stirred at room temperature for 3 days. The resulting precipitate was filtered, washed with dichloromethane and dried to give the title compound (96 mg). UPLC-MS: RT=1.01 min; m/z (ES+) 390.24 [MH+]; required MW=389.46.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US09340528B2 |
| 出典データセット | uspto-grants-2016_05 |
| ORD ID | ord-c8bf5d93196e40dd92f81856387d748b |
| 出典メモ | uspto-grants-2016_05 |