Benzyl Bromide → 4-Benzyloxyphenylacetic acid ethyl ester

HRID 524408

反応式

HRID 524408 の反応式
[C:1](=[O:4])([O-])[O-].[Cs+].[Cs+].[CH2:7](Br)[C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1.[C:15]([O:18][CH2:19][CH3:20])(=[O:17])[CH3:16]>C(#N)C>[CH2:7]([O:4][C:1]1[CH:12]=[CH:13][C:8]([CH2:16][C:15]([O:18][CH2:19][CH3:20])=[O:17])=[CH:9][CH:10]=1)[C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1

参加物

5

反応物 3

HCID 7498Benzyl BromideHCID 8857Ethyl AcetateHCID 10796Cesium carbonate

生成物 1

HCID 27374284-Benzyloxyphenylacetic acid ethyl ester

試薬・触媒・溶媒 1

HCID 6342Acetonitrile溶媒2 回

実験手順

A solution of ethyl-4-hydroxy phenyl acetate (10 g, 55.49 mmol) in 50 mL of dry acetonitrile was added in a drop wise manner to a suspension of cesium carbonate (36 g, 110.98 mmol) in 50 mL of dry acetonitrile. Reaction mixture was allowed to stir at rt for 10 min then benzyl bromide (7.25 mL, 61.03 mmol) was added drop wise and continued to stir overnight at rt. Reaction was quenched with water and solid was filtered through Buchner funnel, filtrate obtained was diluted with ethyl acetate, and organic layer was washed with water, brine and dried over anhydrous sodium sulphate. Solvent was removed under reduced pressure to obtain crude product which was purified using column chromatography using 5-10% ethyl acetate in hexane to afford 8.0 g of liquid.

後処理

  1. customReaction mixture
  2. stirringcontinued to stir overnight at rt
  3. customReaction
  4. customwas quenched with water and solid
  5. filtrationwas filtered through Buchner funnel, filtrate
  6. customobtained
  7. washwas washed with water, brine
  8. dry with materialdried over anhydrous sodium sulphate
  9. customSolvent was removed under reduced pressure
  10. customto obtain crude product which
  11. customwas purified

出典と根拠

ORDレコード
ord-9b3ff5f2fe59417a9b17a840ed433764
出典データセット
uspto-grants-2016_05
特許番号
US09340506B2

関連ノート

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