Formic Acid → N-(4-chlorophenyl)formamide

HRID 524482

反応式

HRID 524482 の反応式
[Cl:1][C:2]1[CH:8]=[CH:7][C:5]([NH2:6])=[CH:4][CH:3]=1.[CH:9](O)=[O:10]>>[Cl:1][C:2]1[CH:8]=[CH:7][C:5]([NH:6][CH:9]=[O:10])=[CH:4][CH:3]=1

参加物

3

反応物 2

HCID 284Formic AcidHCID 78124-Chloroaniline

生成物 1

HCID 17475N-(4-chlorophenyl)formamide収率 97%

実験手順

4-Chloroaniline (15 g, 117 mmol) and formic acid (25 mL, 663 mmol) were heated to reflux for 2 hours. The mixture was concentrated in vacuo. Saturated aqueous sodium hydrogen carbonate was added and the aqueous phase was extracted twice with ethyl acetate. The combined organic phases were dried over magnesium sulphate, filtered and concentrated in vacuo to give N-(4-chloro-phenyl)-formamide (17.6 g, 97%) as a grey crystalline compound.

後処理

  1. temperatureto reflux for 2 hours
  2. concentrationThe mixture was concentrated in vacuo
  3. additionSaturated aqueous sodium hydrogen carbonate was added
  4. extractionthe aqueous phase was extracted twice with ethyl acetate
  5. dry with materialThe combined organic phases were dried over magnesium sulphate
  6. filtrationfiltered
  7. concentrationconcentrated in vacuo

出典と根拠

ORDレコード
ord-5a97fcde4bcd4caa9f3db83e83a390e0
出典データセット
uspto-grants-2016_05
特許番号
US09340544B2

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