Sodium Hydroxide → 4-Methylpiperazine-2-carboxylic acid

反応式

[CH3:1][N:2]1[CH2:7][CH2:6][NH:5][CH:4]([C:8]([O:10]CC)=[O:9])[CH2:3]1.[OH-].[Na+]>>[CH3:1][N:2]1[CH2:7][CH2:6][NH:5][CH:4]([C:8]([OH:10])=[O:9])[CH2:3]1

参加物

反応物 2

HCID 14798Sodium Hydroxide

HCID 12558522Ethyl 4-methylpiperazine-2-carboxylate

生成物 1

HCID 64209034-Methylpiperazine-2-carboxylic acid収率 100%

実験手順

Ethyl 4-methylpiperazine-2-carboxylate (1.03 g, 6 mmol) was reacted with NaOH (0.48 g, 12 mmol) according to the procedure as described in Example 21, Step A to give the title compound as colorless oil (0.86 g, 100%). The compound was characterized by the following spectroscopic data:

出典と根拠

ORDレコード: ord-88397e1baa204780b98e954df8ed3c75
出典データセット: uspto-grants-2016_05
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US09340538B2

反応ノート

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