1-Methyl-4-(3-nitro-4-pyridyl)piperazine → Piperazine, 1-(3-amino-4-pyridyl)-4-methyl-
反応式
[CH3:1][N:2]1[CH2:7][CH2:6][N:5]([C:8]2[CH:13]=[CH:12][N:11]=[CH:10][C:9]=2[N+:14]([O-])=O)[CH2:4][CH2:3]1>CO.[Pd]>[CH3:1][N:2]1[CH2:3][CH2:4][N:5]([C:8]2[CH:13]=[CH:12][N:11]=[CH:10][C:9]=2[NH2:14])[CH2:6][CH2:7]1参加物
4
実験手順
1-methyl-4-(3-nitro-4-pyridyl)piperazine 14 (2.56 g, 11.52 mmol) in methanol (200 mL) was treated with palladium on carbon (10% wt % Degussa) (300 mg) and hydrogenated under balloon pressure at RT for 3 hours. The catalyst was filtered off and the filtrate was concentrated under reduced pressure to give 4-(4-methylpiperazin-1-yl)pyridin-3-amine 15 as a colourless solid (2.124 g, 11.05 mmol, 95.89%). MS (ES+) 193.1.
後処理
- filtrationThe catalyst was filtered off
- concentrationthe filtrate was concentrated under reduced pressure
出典と根拠
- ORDレコード
- ord-a274879ee2c240a49f1b5bf42142de87
- 出典データセット
- uspto-grants-2016_05
- 特許番号
- US09340546B2
反応ノート
読み込み中…