Acetohydrazide → HCID 86720972、化合物
反応式
[Br:1][C:2]1[CH:3]=[N:4][CH:5]=[CH:6][C:7]=1[N:8]=[C:9]=[S:10].[C:11]([NH:14][NH2:15])(=[O:13])[CH3:12]>O1CCOCC1.CCOCC>[C:11]([NH:14][NH:15][C:9](=[S:10])[NH:8][C:7]1[CH:6]=[CH:5][N:4]=[CH:3][C:2]=1[Br:1])(=[O:13])[CH3:12]参加物
5
反応条件
- 温度
- 80 °C
実験手順
3-bromo-4-isothiocyanato-pyridine (1 g, 4.650 mmol) and acetylhydrazine (344.5 mg, 4.650 mmol) were dissolved in dry 1,4-dioxane (10 mL) and stirred at 80° C. for 0.75 hrs. The orange suspension was allowed to cool to RT. The viscous suspension was diluted with ether and the solid was collected by filtration and washed with ether (3×5 mL) to give 2-acetyl-N-(3-bromopyridin-4-yl)hydrazinecarbothioamide as a salmon-pink solid (1.2187 g, 91% Yield). MS (ES−) 288.9.
後処理
- temperatureto cool to RT
- filtrationthe solid was collected by filtration
- washwashed with ether (3×5 mL)
出典と根拠
- ORDレコード
- ord-e106e0a0f7244b5590e48fb721deb1dd
- 出典データセット
- uspto-grants-2016_05
- 特許番号
- US09340546B2
反応ノート
読み込み中…