O-Toluidine → HCID 70922270、化合物

HRID 524975ノート

反応式

HRID 524975 の反応式
ClC(Cl)(Cl)[C:3]([C:5]1[NH:6][CH:7]=[C:8]([CH3:10])[CH:9]=1)=[O:4].[NH2:13][C:14]1[C:15]([CH3:20])=[CH:16][CH:17]=[CH:18][CH:19]=1.C(N(CC)CC)C>CCCCCC>[CH3:10][C:8]1[CH:9]=[C:5]([C:3]([NH:13][C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][C:15]=2[CH3:20])=[O:4])[NH:6][CH:7]=1

参加物

5

反応物 3

HCID 7242O-ToluidineHCID 8471TriethylamineHCID 70922409HCID 70922409、化合物

生成物 1

HCID 70922270HCID 70922270、化合物収率 45%

試薬・触媒・溶媒 1

HCID 8058Hexane溶媒

反応条件

温度
80 °C

実験手順

A solution of 2,2,2-trichloro-1-(4-methyl-1H-pyrrol-2-yl)ethanone (2 g, 8.8 mmol) in a mixture of o-toluidine (1.76 mL, 16.5 mmol) and triethylamine (2.1 mL, 15.07 mmol) under argon was heated to 80° C. with stirring during 75 h. Afterwards, the reaction mixture was concentrated to dryness giving a residue that was treated with hexane and the resulting solid filtered to afford 848 mg of the title compound (45% yield).

後処理

  1. concentrationAfterwards, the reaction mixture was concentrated to dryness
  2. customgiving a residue that
  3. filtrationthe resulting solid filtered

出典と根拠

ORDレコード
ord-c7e70a85971b4183999c5a069e4e05d2
出典データセット
uspto-grants-2016_05
特許番号
US09340547B2

反応ノート

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