2-(((Tert-butoxy)carbonyl)amino)butanoic acid → tert-Butyl 1-oxo-1-(2-(phenylcarbamoyl)-1H-pyrrol-1-ylamino)propan-2-ylcarbamate

HRID 524978

反応式

HRID 524978 の反応式
[NH2:1][N:2]1[CH:6]=[CH:5][CH:4]=[C:3]1[C:7]([NH:9][C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1)=[O:8].[C:16]([O:20][C:21]([NH:23][CH:24]([CH2:28]C)[C:25](O)=[O:26])=[O:22])([CH3:19])([CH3:18])[CH3:17]>C(OCC)C>[O:26]=[C:25]([NH:1][N:2]1[CH:6]=[CH:5][CH:4]=[C:3]1[C:7](=[O:8])[NH:9][C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1)[CH:24]([NH:23][C:21](=[O:22])[O:20][C:16]([CH3:19])([CH3:18])[CH3:17])[CH3:28]

参加物

4

反応物 2

HCID 3335222-(((Tert-butoxy)carbonyl)amino)butanoic acidHCID 709224541-amino-N-phenyl-1H-pyrrole-2-carboxamide

生成物 1

HCID 70922143tert-Butyl 1-oxo-1-(2-(phenylcarbamoyl)-1H-pyrrol-1-ylamino)propan-2-ylcarbamate収率 87.6%

試薬・触媒・溶媒 1

HCID 3283Diethyl Ether溶媒

実験手順

The title compound was prepared following the experimental procedure described in preparation 20a from 1.50 g (7.45 mmol) of 1-amino-N-phenyl-1H-pyrrole-2-carboxamide and 1.82 g (8.95 mmol) of racemic 2-(tert-butoxycarbonylamino)butanoic acid (purchased from ABCR, cat. no. AB154485). After recristallysation of the crude product in diethylether, 2.43 g (84% yield) of the title compound were obtained.

後処理

  1. customThe title compound was prepared

出典と根拠

ORDレコード
ord-2c32fb8c08414f52acc2d661f579da4b
出典データセット
uspto-grants-2016_05
特許番号
US09340547B2

関連ノート

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