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3,5-Dichloroaniline → 3-Bromo-N-(3,5-dichlorophenyl)-1-(phenylsulfonyl)-1H-pyrrole-2-carboxamide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 3,5-Dichloroaniline | HCID 12281 | — |
| 反応物 | Methyl 3-bromo-1-(phenylsulfonyl)-1H-pyrrole-2-carboxylate | HCID 44518095 | — |
| 生成物 | 3-Bromo-N-(3,5-dichlorophenyl)-1-(phenylsulfonyl)-1H-pyrrole-2-carboxamide | HCID 70981361 | 96% |
反応手順
Prepared from 2.00 g (5.81 mmol) of methyl 3-bromo-1-(phenylsulfonyl)-1H-pyrrole-2-carboxylate and 2.82 g (17.41 mmol) of 3,5-dichloroaniline following the experimental procedure described in Preparation 44a. The product was purified by flash chromatography (0% to 40% hexane/AcOEt) to give 2.64 g (96% yield) of the title compound as a beige solid.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US09340547B2 |
| 出典データセット | uspto-grants-2016_05 |
| ORD ID | ord-163acc9cf55841f98c7120bd0d8683c0 |
| 出典メモ | uspto-grants-2016_05 |