2-Pyridinemethanamine → (S)-tert-Butyl 1-(3-bromo-2-(pyridin-2-ylmethylcarbamoyl)-1H-pyrrol-1-ylamino)-1-oxopropan-2-ylcarbamate

HRID 525010

反応式

HRID 525010 の反応式
[Br:1][C:2]1[CH:6]=[CH:5][N:4]([NH:7][C:8](=[O:19])[C@@H:9]([NH:11][C:12]([O:14][C:15]([CH3:18])([CH3:17])[CH3:16])=[O:13])[CH3:10])[C:3]=1[C:20]([O:22]C)=O.[N:24]1[CH:29]=[CH:28][CH:27]=[CH:26][C:25]=1[CH2:30][NH2:31]>>[Br:1][C:2]1[CH:6]=[CH:5][N:4]([NH:7][C:8](=[O:19])[C@@H:9]([NH:11][C:12](=[O:13])[O:14][C:15]([CH3:16])([CH3:17])[CH3:18])[CH3:10])[C:3]=1[C:20](=[O:22])[NH:31][CH2:30][C:25]1[CH:26]=[CH:27][CH:28]=[CH:29][N:24]=1

参加物

3

反応物 2

HCID 195092-PyridinemethanamineHCID 86722018(S)-Methyl 3-bromo-1-(2-(tert-butoxycarbonylamino)propanamido)-1H-pyrrole-2-carboxylate

生成物 1

HCID 86722030(S)-tert-Butyl 1-(3-bromo-2-(pyridin-2-ylmethylcarbamoyl)-1H-pyrrol-1-ylamino)-1-oxopropan-2-ylcarbamate

実験手順

Same procedure as described in preparation 133a was used from (S)-methyl 3-bromo-1-(2-(tert-butoxycarbonylamino)propanamido)-1H-pyrrole-2-carboxylate (374 mg, 0.96 mmols) and pyridine-2-ylmethanamine (0.30 ml, 2.87 mmols). After reverse phase chromatography the title compound was obtained (74 mg, 17%).

出典と根拠

ORDレコード
ord-7924540c81e04da7a4c919b93d5390ce
出典データセット
uspto-grants-2016_05
特許番号
US09340547B2

関連ノート

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