反応式
[Br:1][C:2]1[CH:6]=[CH:5][N:4]([NH:7][C:8](=[O:19])[C@@H:9]([NH:11][C:12]([O:14][C:15]([CH3:18])([CH3:17])[CH3:16])=[O:13])[CH3:10])[C:3]=1[C:20]([O:22]C)=O.[Cl:24][C:25]1[CH:30]=[CH:29][CH:28]=[CH:27][C:26]=1[CH2:31][NH2:32]>>[Br:1][C:2]1[CH:6]=[CH:5][N:4]([NH:7][C:8](=[O:19])[C@@H:9]([NH:11][C:12](=[O:13])[O:14][C:15]([CH3:16])([CH3:17])[CH3:18])[CH3:10])[C:3]=1[C:20](=[O:22])[NH:32][CH2:31][C:26]1[CH:27]=[CH:28][CH:29]=[CH:30][C:25]=1[Cl:24]参加物
3
実験手順
The title compound was prepared from (S)-Methyl 3-bromo-1-(2-(tert-butoxycarbonylamino)propanamido)-1H-pyrrole-2-carboxylate (310 mg, 0.8 mmol) and (2-chlorophenyl)methanamine (385 μL, 3.2 mmol) following the experimental procedure described in Preparation 44a. 259 mg (65% yield) of the desired compound were obtained.
出典と根拠
- ORDレコード
- ord-f4767860006d4c1aa19e5a4d7d507dc3
- 出典データセット
- uspto-grants-2016_05
- 特許番号
- US09340547B2
関連ノート
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