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2-Chlorobenzylamine → (S)-tert-Butyl 1-(3-bromo-2-(2-chlorobenzylcarbamoyl)-1H-pyrrol-1-ylamino)-1-oxopropan-2-ylcarbamate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 2-Chlorobenzylamine | HCID 66648 | — |
| 反応物 | (S)-Methyl 3-bromo-1-(2-(tert-butoxycarbonylamino)propanamido)-1H-pyrrole-2-carboxylate | HCID 86722018 | — |
| 生成物 | (S)-tert-Butyl 1-(3-bromo-2-(2-chlorobenzylcarbamoyl)-1H-pyrrol-1-ylamino)-1-oxopropan-2-ylcarbamate | HCID 86722048 | 65% |
反応手順
The title compound was prepared from (S)-Methyl 3-bromo-1-(2-(tert-butoxycarbonylamino)propanamido)-1H-pyrrole-2-carboxylate (310 mg, 0.8 mmol) and (2-chlorophenyl)methanamine (385 μL, 3.2 mmol) following the experimental procedure described in Preparation 44a. 259 mg (65% yield) of the desired compound were obtained.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US09340547B2 |
| 出典データセット | uspto-grants-2016_05 |
| ORD ID | ord-f4767860006d4c1aa19e5a4d7d507dc3 |
| 出典メモ | uspto-grants-2016_05 |