N-carbobenzyloxyalanine → (S)-Methyl 1-(2-(benzyloxycarbonylamino)propanamido)-3-Bromo-1H-Pyrrole-2-carboxylate

HRID 525030

反応式

HRID 525030 の反応式
[NH2:1][N:2]1[CH:6]=[CH:5][C:4]([Br:7])=[C:3]1[C:8]([O:10][CH3:11])=[O:9].[CH2:12]([O:19][C:20]([NH:22][C@@H:23]([CH3:27])[C:24](O)=[O:25])=[O:21])[C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1>>[CH2:12]([O:19][C:20]([NH:22][C@@H:23]([CH3:27])[C:24]([NH:1][N:2]1[CH:6]=[CH:5][C:4]([Br:7])=[C:3]1[C:8]([O:10][CH3:11])=[O:9])=[O:25])=[O:21])[C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1

参加物

3

反応物 2

HCID 736104N-carbobenzyloxyalanineHCID 70979762methyl 1-amino-3-bromo-1H-pyrrole-2-carboxylate

生成物 1

HCID 86722049(S)-Methyl 1-(2-(benzyloxycarbonylamino)propanamido)-3-Bromo-1H-Pyrrole-2-carboxylate収率 89.6%

実験手順

The title compound was prepared from methyl 1-amino-3-bromo-1H-pyrrole-2-carboxylate (9.05 g, 25.6 mmol) and (S)-2-(benzyloxycarbonylamino)propanoic acid (5.72 g, 25.6 mmol) following the experimental procedure described in Preparation 73a. 9.73 g (84% yield) of the desired compound were obtained.

出典と根拠

ORDレコード
ord-b2e06ac5adc74ca9a1c9c1efe94f92a2
出典データセット
uspto-grants-2016_05
特許番号
US09340547B2

関連ノート

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