2-Amino-6-(trifluoromethyl)pyridine → (S)-Benzyl 1-(3-bromo-2-(6-(trifluoromethyl)pyridin-2-ylcarbamoyl)-1H-pyrrol-1-ylamino)-1-oxopropan-2-ylcarbamate

HRID 525034

反応式

HRID 525034 の反応式
[CH2:1]([O:8][C:9]([NH:11][C@@H:12]([CH3:26])[C:13]([NH:15][N:16]1[CH:20]=[CH:19][C:18]([Br:21])=[C:17]1[C:22]([O:24]C)=O)=[O:14])=[O:10])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[F:27][C:28]([F:37])([F:36])[C:29]1[N:34]=[C:33]([NH2:35])[CH:32]=[CH:31][CH:30]=1>>[Br:21][C:18]1[CH:19]=[CH:20][N:16]([NH:15][C:13](=[O:14])[C@@H:12]([NH:11][C:9](=[O:10])[O:8][CH2:1][C:2]2[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=2)[CH3:26])[C:17]=1[C:22](=[O:24])[NH:35][C:33]1[CH:32]=[CH:31][CH:30]=[C:29]([C:28]([F:36])([F:27])[F:37])[N:34]=1

参加物

3

反応物 2

HCID 8210242-Amino-6-(trifluoromethyl)pyridineHCID 86722049(S)-Methyl 1-(2-(benzyloxycarbonylamino)propanamido)-3-Bromo-1H-Pyrrole-2-carboxylate

生成物 1

HCID 86722053(S)-Benzyl 1-(3-bromo-2-(6-(trifluoromethyl)pyridin-2-ylcarbamoyl)-1H-pyrrol-1-ylamino)-1-oxopropan-2-ylcarbamate収率 51%

実験手順

The title compound was prepared from (S)-methyl 1-(2-(benzyloxycarbonylamino)propanamido)-3-bromo-1H-pyrrole-2-carboxylate (2.00 g, 4.7 mmol) and 6-(trifluoromethyl)pyridin-2-amine (3.00 g, 18.5 mmol) following the experimental procedure described in Preparation 44a. 1.32 g (51% yield) of the desired compound were obtained.

出典と根拠

ORDレコード
ord-ed12ed702594484a830867559399ecc0
出典データセット
uspto-grants-2016_05
特許番号
US09340547B2

関連ノート

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