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O-Benzyl-N-(tert-butoxycarbonyl)-L-homoserine → (S)-Methyl 1-(4-(benzyloxy)-2-(tert-butoxycarbonylamino)butanamido)-3-bromo-1H-pyrrole-2-carboxylate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | O-Benzyl-N-(tert-butoxycarbonyl)-L-homoserine | HCID 15058464 | — |
| 反応物 | methyl 1-amino-3-bromo-1H-pyrrole-2-carboxylate | HCID 70979762 | — |
| 生成物 | (S)-Methyl 1-(4-(benzyloxy)-2-(tert-butoxycarbonylamino)butanamido)-3-bromo-1H-pyrrole-2-carboxylate | HCID 86722060 | 93% |
反応手順
The title compound was prepared from methyl 1-amino-3-bromo-1H-pyrrole-2-carboxylate (2.83 g, 12.9 mmol) and (S)-4-(benzyloxy)-2-(tert-butoxycarbonylamino)butanoic acid (4.0 g, 12.9 mmol) following the experimental procedure described in Preparation 73a. 6.12 g (93% yield) of the desired compound were obtained.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US09340547B2 |
| 出典データセット | uspto-grants-2016_05 |
| ORD ID | ord-a80f5feec49146be99b70067b94a9468 |
| 出典メモ | uspto-grants-2016_05 |