化工社化工社 化学情報印刷レポート · 研究参考用
3-(Diethylboryl)pyridine → Abiraterone Acetate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 3-(Diethylboryl)pyridine | HCID 642851 | — |
| 反応物 | ((3S,8R,9S,10R,13S,14S)-10,13-dimethyl-17-(trifluoromethylsulfonyloxy)-2,3,4,7,8,9,11,12,14,15-decahydro-1H-cyclopenta(a)phenanthren-3-yl) acetate | HCID 10457059 | — |
| 生成物 | Abiraterone Acetate | HCID 9821849 | — |
反応手順
The Suzuki reaction between 3β-acetoxyandrosta-5,16-dien-17-yl trifluoromethanesulphonate (II) and diethyl(3-pyridyl)borane affords crude abiraterone acetate which is purified by silica gel chromatography, eluting with a mixture of ethyl ether and petroleum ether, and finally crystallised from hexane.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US09340571B2 |
| 出典データセット | uspto-grants-2016_05 |
| ORD ID | ord-6bad42bc2af8438bbf7cc845c0ea09b4 |
| 出典メモ | uspto-grants-2016_05 |