C(=O)([O-])[O-].[Cs+].[Cs+].[Br:7][C:8]1[CH:9]=[C:10]2[C:15](=[CH:16][CH:17]=1)[N:14]=[C:13]([OH:18])[N:12]=[CH:11]2.C(O)(C)(C)C.C1(C)C=CC=CC=1.CC(=O)CC.[C:36]([CH:40]1[CH2:45][CH2:44][CH:43](OS(C)(=O)=O)[CH2:42][CH2:41]1)([CH3:39])([CH3:38])[CH3:37]>>[Br:7][C:8]1[CH:9]=[C:10]2[C:15](=[CH:16][CH:17]=1)[N:14]=[C:13]([O:18][CH:43]1[CH2:44][CH2:45][CH:40]([C:36]([CH3:39])([CH3:38])[CH3:37])[CH2:41][CH2:42]1)[N:12]=[CH:11]2Cesium carbonate (3.1308 g, 9.6089 mmol) was added to a mixture of 6-bromoquinazolin-2-ol (1.0812 g, 4.8044 mmol) in tert-butyl alcohol (15 mL, 160 mmol), toluene (25 mL, 230 mmol) and 2-butanone (10 mL, 100 mmol). The mixture was heated at 110° C. for 1 hour in a sealed tube then cooled to room temperature and methanesulfonic acid 4-tert-butyl-cyclohexyl ester (2.2519 g, 9.6089 mmol) was added. The reaction was then heated at 110° C. overnight. The reaction mixture was cooled to room temperature then filtered through a pad of celite. The filtrate was concentrated under reduced pressure, adsorbed onto silica gel and purified by flash chromatography (80 g SiO2 column; 0-40% EtOAc in heptane eluent) to give the title compound in 20% yield. ESI-MS (M+H+): 365.1
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