Pyridine → N-((6-bromothiazolo[5,4-b]pyridin-2-yl)methyl)methanesulfonamide

HRID 525601ノート

反応式

HRID 525601 の反応式
[Br:1][C:2]1[CH:3]=[C:4]2[N:10]=[C:9]([CH2:11][NH2:12])[S:8][C:5]2=[N:6][CH:7]=1.N1C=CC=CC=1.[CH3:19][S:20](Cl)(=[O:22])=[O:21]>C(Cl)Cl>[Br:1][C:2]1[CH:3]=[C:4]2[N:10]=[C:9]([CH2:11][NH:12][S:20]([CH3:19])(=[O:22])=[O:21])[S:8][C:5]2=[N:6][CH:7]=1

参加物

5

反応物 3

HCID 1049PyridineHCID 31297Methanesulfonyl chlorideHCID 86695491(6-Bromothiazolo[5,4-b]pyridin-2-yl)methanamine

生成物 1

HCID 86695490N-((6-bromothiazolo[5,4-b]pyridin-2-yl)methyl)methanesulfonamide収率 75.7%

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

To a cooled (ice-water) solution of (6-bromothiazolo[5,4-b]pyridin-2-yl)methanamine (800 mg, 3.28 mmol) and pyridine (800 mg, 9.85 mmol) in CH2Cl2 (10 mL) is slowly added methanesulfonyl chloride (380 mg, 3.28) and stirred at room temperature for 3 hours. Reaction mixture is washed with water (2×10 mL) dried over Na2SO4 and concentrated. Obtained crude product purified on silica gel column using 0 to 5% methanol/CH2Cl2 to give the title compound (800 mg): m/z (Cl) M+2 324.

後処理

  1. customReaction mixture
  2. washis washed with water (2×10 mL)
  3. dry with materialdried over Na2SO4
  4. concentrationconcentrated
  5. customObtained crude product
  6. custompurified on silica gel column

出典と根拠

ORDレコード
ord-4a75f0c70b86494f9741152c3b33726d
出典データセット
uspto-grants-2016_05
特許番号
US09340564B2

反応ノート

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