1-Fluoro-2,3-dimethoxy-5-nitrobenzene → 3-Fluoro-4,5-dimethoxyaniline

HRID 525932ノート

反応式

HRID 525932 の反応式
[F:1][C:2]1[CH:7]=[C:6]([N+:8]([O-])=O)[CH:5]=[C:4]([O:11][CH3:12])[C:3]=1[O:13][CH3:14]>C(O)C.[Pt](=O)=O>[F:1][C:2]1[CH:7]=[C:6]([CH:5]=[C:4]([O:11][CH3:12])[C:3]=1[O:13][CH3:14])[NH2:8]

参加物

4

反応物 1

HCID 153116921-Fluoro-2,3-dimethoxy-5-nitrobenzene

生成物 1

HCID 574295473-Fluoro-4,5-dimethoxyaniline収率 94.2%

試薬・触媒・溶媒 2

HCID 345198Adams' catalyst触媒HCID 702Ethanol溶媒

実験手順

A mixture of 1-fluoro-2,3-dimethoxy-5-nitrobenzene (91 g, 452 mmol) and platinum(IV) oxide (9 g, 39.6 mmol) in ethanol (500 mL) was hydrogenated with a Par shaker (40 psi) at r.t. for 30 min. LCMS indicated completion of the reaction. The mixture was filtered and the filtrate was concentrated to afford 3-fluoro-4,5-dimethoxyaniline (73 g, 426 mmol, 94% yield) as a brown oil that was directly used in next step. LCMS: (M+H)+:171.9.

後処理

  1. customcompletion of the reaction
  2. filtrationThe mixture was filtered
  3. concentrationthe filtrate was concentrated

出典と根拠

ORDレコード
ord-98877b83722944bf9a39986f098cfcf5
出典データセット
uspto-grants-2016_05
特許番号
US09340556B2

反応ノート

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