Ammonium Hydroxide → 2-Amino-1-methylcyclohexan-1-ol

HRID 526967

反応式

HRID 526967 の反応式
[CH3:1][C:2]12[O:8][CH:7]1[CH2:6][CH2:5][CH2:4][CH2:3]2.[OH-].[NH4+:10]>O>[NH2:10][CH:7]1[CH2:6][CH2:5][CH2:4][CH2:3][C:2]1([CH3:1])[OH:8]

参加物

4

反応物 2

HCID 14923Ammonium HydroxideHCID 2242431-Methyl-1,2-epoxycyclohexane2 回

生成物 1

HCID 203650302-Amino-1-methylcyclohexan-1-ol

試薬・触媒・溶媒 1

HCID 962Water溶媒2 回

反応条件

温度
50 °C

実験手順

To a solution of 1-methyl-7-oxabicyclo[4.1.0]heptane, 30a, (1.0 g, 7.1 mmol) in water was added ammonium hydroxide (6.0 mL, 154.1 mmol). The mixture was heated to 50° C. for 48 hours. The mixture was diluted with water, extracted with EtOAc and then twice with 20% MeOH/CHCl3. The organic phases were dried (MgSO4), filtered and concentrated in vacuo to provide the desired product, 30b, as an amorphous white solid.

後処理

  1. extractionextracted with EtOAc
  2. dry with materialThe organic phases were dried (MgSO4)
  3. filtrationfiltered
  4. concentrationconcentrated in vacuo

出典と根拠

ORDレコード
ord-b67315c040f44fbba5c5f73e9b24f4e5
出典データセット
uspto-grants-2016_05
特許番号
US09345708B2

関連ノート

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