HCID 67287398、化合物 → HCID 67286790、化合物

HRID 527015ノート

反応式

HRID 527015 の反応式
[CH2:1]([O:8][CH:9]1[CH2:14][CH2:13][CH2:12][CH:11]([O:15]C)[CH:10]1[O:17][Si:18]([C:21]([CH3:24])([CH3:23])[CH3:22])([CH3:20])[CH3:19])C1C=CC=CC=1>C(OCC)(=O)C.[H][H].[Pd]>[OH:15][CH:11]1[CH2:12][CH2:13][CH2:14][CH:9]([O:8][CH3:1])[CH:10]1[O:17][Si:18]([C:21]([CH3:24])([CH3:23])[CH3:22])([CH3:20])[CH3:19]

参加物

5

反応物 1

HCID 67287398HCID 67287398、化合物2 回

生成物 1

HCID 67286790HCID 67286790、化合物

試薬・触媒・溶媒 3

HCID 8857Ethyl Acetate溶媒HCID 23938Palladium溶媒HCID 178418361HCID 178418361、化合物溶媒

実験手順

A solution of racemic [1-benzyloxy-3-methoxy-2-cyclohexanoxy]tert-butyl-dimethylsilane, 51e, (3.4 g, 9.7 mmol) was dissolved in ethyl acetate (50 mL) and hydrogenated under 45 PSI of hydrogen with Pd—C 10% for 1 h. The reaction mixture was filtered over a nylon/fiberglass filter to provide, after concentration in vacuo 2.72 g of desired product 51f. This material was used directly in the next step without further purification.

後処理

  1. filtrationThe reaction mixture was filtered over a nylon/fiberglass
  2. filtrationfilter
  3. customto provide
  4. concentrationafter concentration in vacuo 2.72 g of desired product 51f
  5. customThis material was used directly in the next step without further purification

出典と根拠

ORDレコード
ord-89cb5cd557a94f208c8f6d8168422e78
出典データセット
uspto-grants-2016_05
特許番号
US09345708B2

反応ノート

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