Hydrochloric Acid → 3-Amino-2-hydroxycyclohexane-1-carboxylic acid

HRID 527058ノート

反応式

HRID 527058 の反応式
[OH:1][C:2]1[C:10]([N+:11]([O-])=O)=[CH:9][CH:8]=[CH:7][C:3]=1[C:4]([OH:6])=[O:5].Cl>O=[Pt]=O>[NH2:11][CH:10]1[CH2:9][CH2:8][CH2:7][CH:3]([C:4]([OH:6])=[O:5])[CH:2]1[OH:1]

参加物

4

反応物 2

HCID 313Hydrochloric AcidHCID 68073-Nitrosalicylic acid

生成物 1

HCID 672865413-Amino-2-hydroxycyclohexane-1-carboxylic acid

試薬・触媒・溶媒 1

HCID 345198Adams' catalyst触媒

実験手順

2-Hydroxy-3-nitro-benzoic acid (5.0 g, 27.3 mmol) was mixed with HCl (125 mL of 0.5 M, 62.5 mmol) and dioxoplatinum (1.0 g, 4.4 mmol) in a hydrogenation bottle. The mixture was placed on a Parr shaker (50 psi H2) for 24 hours. The catalyst was filtered and washed with hot H2O. The filtrate was evaporated to provide 3-amino-2-hydroxy-cyclohexanecarboxylic acid as a mixture of stereoisomers which was utilized to the next step without further purification.

後処理

  1. filtrationThe catalyst was filtered
  2. washwashed with hot H2O
  3. customThe filtrate was evaporated

出典と根拠

ORDレコード
ord-cf6bcba6db304c449b33de6ed56e92f1
出典データセット
uspto-grants-2016_05
特許番号
US09345708B2

反応ノート

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