Trifluoroacetic acid → 6-Aminobicyclo(2.2.1)heptane-2-carboxylic acid

HRID 527089ノート

反応式

HRID 527089 の反応式
C(OC([NH:8][CH:9]1[CH:14]2[CH2:15][CH:11]([CH2:12][CH:13]2[C:16]([OH:18])=[O:17])[CH2:10]1)=O)(C)(C)C.FC(F)(F)C(O)=O>ClCCl>[NH2:8][CH:9]1[CH:14]2[CH2:15][CH:11]([CH2:12][CH:13]2[C:16]([OH:18])=[O:17])[CH2:10]1

参加物

4

反応物 2

HCID 6422Trifluoroacetic acidHCID 672859386-(Tert-butoxycarbonylamino)norbornane-2-carboxylic acid

生成物 1

HCID 206527796-Aminobicyclo(2.2.1)heptane-2-carboxylic acid

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

A solution of 6-(tert-butoxycarbonylamino)norbornane-2-carboxylic acid, 72g, in dichloromethane (5 mL) was treated with trifluoroacetic acid (5 mL) for 1 hour at room temperature. The solvent was evaporated under reduced pressure and the resulting product was dissolved in 2 mL TFA and added to a stirring 1N HCl in Et2O solution. After stirring the mixture for 0.5 hour, the resulting precipitate was filtered and washed with dry Et2O to give 6-aminobicyclo[2.2.1]heptane-2-carboxylic acid.

後処理

  1. customThe solvent was evaporated under reduced pressure
  2. dissolutionthe resulting product was dissolved in 2 mL TFA
  3. additionadded to a stirring 1N HCl in Et2O solution
  4. filtrationthe resulting precipitate was filtered
  5. washwashed with dry Et2O

出典と根拠

ORDレコード
ord-bd0c1d42ef6a40ef8c9170c9b043b8d5
出典データセット
uspto-grants-2016_05
特許番号
US09345708B2

反応ノート

読み込み中…