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2-Cyano-3,3-bis(methylthio)acrylamide → 2-Cyano-3-((4-(4-isopropylpiperazin-1-yl)phenyl)amino)-3-(methylthio)acrylamide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 2-Cyano-3,3-bis(methylthio)acrylamide | HCID 2747746 | — |
| 反応物 | 4-[4-(Propan-2-yl)piperazin-1-yl]aniline | HCID 9161545 | — |
| 溶媒 | Ethanol | HCID 702 | — |
| 生成物 | 2-Cyano-3-((4-(4-isopropylpiperazin-1-yl)phenyl)amino)-3-(methylthio)acrylamide | HCID 86701874 | — |
反応手順
Dissolved 0.500 g 2-cyano-3,3-bis(methylthio)acrylamide in 15 mL EtOH and added 4-(4-(2-propyl)-piperazin-1-yl)aniline (1.0 eq.). Stirred reaction at 75° C. until starting amide was absent by HPLC. Once complete (18 hrs), reaction was brought to room temperature and filtered to obtain 2-cyano-3-((4-(4-isopropylpiperazin-1-yl)phenyl)amino)-3-(methylthio)acrylamide as a purple powder. Product was allowed to dry under vacuum for 1 hr.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US09346792B2 |
| 出典データセット | uspto-grants-2016_05 |
| ORD ID | ord-8cce96dbee7e4f49bcaeb9650bf1353d |
| 出典メモ | uspto-grants-2016_05 |