化工社化工社 化学情報印刷レポート · 研究参考用
1-(2-isopropyloxazol-4-yl)-N-methylmethanamine → N-((N-Methyl-N-((2-isopropyl-4-oxazolyl)methyl)amino)carbonyl)-L-alanine Methyl Ester
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 1-(2-isopropyloxazol-4-yl)-N-methylmethanamine | HCID 10820784 | — |
| 反応物 | Methyl N-[(4-nitrophenoxy)carbonyl]-L-valinate | HCID 15344176 | — |
| 反応物 | N-(((4-nitrophenyl)oxy)carbonyl)-L-alanine methyl ester | HCID 54298210 | — |
| 生成物 | N-((N-Methyl-N-((2-isopropyl-4-oxazolyl)methyl)amino)carbonyl)-L-alanine Methyl Ester | HCID 10708114 | 66% |
反応手順
Using the procedure of Example 1S, but replacing 2-isopropyl-4-(((N-methyl)amino)methyl)thiazole with 2-isopropyl-4-(((N-methyl)amino)methyl)-oxazole and relacing N-(((4-nitrophenyl)oxy)carbonyl)-L-valine methyl ester with N-(((4-nitrophenyl)oxy)carbonyl)-L-alanine methyl ester provided the desired compound in 66% yield. 1H NMR (CDCl3) δ1.32 (d, 6H), 1.42 (d, 3H), 2.96 (s, 3H), 3.05 (m, 1H), 3.75 (s, 3H), 4.30 (s, 2H), 4.47 (m, 1H), 5.80 (br d, 1H), 7.46 (s, 1H). Mass spectrum: (M+H)+ =284.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05616720 |
| 出典データセット | uspto-grants-1997_04 |
| ORD ID | ord-636ca2154b8340fd87a2cf1b2626271e |
| 出典メモ | uspto-grants-1997_04 |