Hydrochloric Acid → 3-Methyl-1,2-benzoxazol-4-ol

HRID 527513ノート

反応式

HRID 527513 の反応式
C(O[N:5]=[C:6]([C:8]1[C:13]([OH:14])=[CH:12][CH:11]=[CH:10][C:9]=1[OH:15])[CH3:7])(=O)C.Cl>N1C=CC=CC=1>[CH3:7][C:6]1[C:8]2=[C:13]([OH:14])[CH:12]=[CH:11][CH:10]=[C:9]2[O:15][N:5]=1

参加物

4

反応物 2

HCID 313Hydrochloric AcidHCID 1363786471-(2,6-dihydroxyphenyl)ethanone O-acetyloxime2 回

生成物 1

HCID 1354299403-Methyl-1,2-benzoxazol-4-ol収率 44%

試薬・触媒・溶媒 1

HCID 1049Pyridine溶媒

実験手順

To 1-(2,6-dihydroxyphenyl)ethanone O-acetyloxime (Intermediate 9, 437 mg) pyridine (4.0 ml) was added and the reaction mixture was stirred at reflux for 2 hours. After the addition of HCl (4.0 ml of a 5M aqueous solution), the mixture was extracted 3 times with Et2O and the collected organic layers were washed with HCl (1M, aqueous solution). The organic phase was dried over sodium sulphate and filtered. Evaporation afforded the title compound (137 mg).

後処理

  1. temperatureat reflux for 2 hours
  2. extractionwas extracted 3 times with Et2O
  3. washthe collected organic layers were washed with HCl (1M, aqueous solution)
  4. dry with materialThe organic phase was dried over sodium sulphate
  5. filtrationfiltered
  6. customEvaporation

出典と根拠

ORDレコード
ord-adb870abfde14683b2b7cbd03bf0518f
出典データセット
uspto-grants-2016_05
特許番号
US09346790B2

反応ノート

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