2-Chloroethanol → 2-Chloroethyl 3-hydroxybenzoate

HRID 52759

反応式

HRID 52759 の反応式
[OH:1][C:2]1[CH:3]=[C:4]([CH:8]=[CH:9][CH:10]=1)[C:5]([OH:7])=[O:6].[Cl:11][CH2:12][CH2:13]O>S(=O)(=O)(O)O.C(OCC)(=O)C>[OH:1][C:2]1[CH:3]=[C:4]([CH:8]=[CH:9][CH:10]=1)[C:5]([O:7][CH2:13][CH2:12][Cl:11])=[O:6]

参加物

5

反応物 2

HCID 342-ChloroethanolHCID 74203-Hydroxybenzoic Acid

生成物 1

HCID 151587912-Chloroethyl 3-hydroxybenzoate収率 95.2%

試薬・触媒・溶媒 2

HCID 1118Sulfuric Acid溶媒HCID 8857Ethyl Acetate溶媒

実験手順

A solution of 3-hydroxybenzoic acid (15.0 g, 0.11 mol) in 2-chloroethanol (70 mL, 1.0 mol) and 1 mL of concentrated sulfuric acid was refluxed for overnight. TLC analysis (silica gel/20% ethyl acetate/hexane) showed clean conversion to a new material. The excess chloroethanol was removed by evaporation to obtain a brown solution which was dissolved in ethyl acetate and washed with water. The organic layer was dried with MgSO4 and concentrated to obtain 21.0 g of the product as a white solid: mp 50° C.; 1H NMR (CDCl3) δ 3.81 (t, 2H, J=5.9 MHz), 4.57 (t, 2H, J=5.9 MHz), 4.77 (s, 1H), 7.06-7.66 (m, 4H); 13C NMR (CDCl3) δ 41.52, 64.75, 116.43, 120.77, 121.98, 129.80, 130.71,156.04, 166.57; MS m/e (tel intensity) 200 (26), 138 (59), 121 (100), 93 (31), 65 (21), 39 (12); Exact mass: calcd 200.0240, found 200.0242. ##STR28##

後処理

  1. customThe excess chloroethanol was removed by evaporation
  2. customto obtain a brown solution which
  3. washwashed with water
  4. dry with materialThe organic layer was dried with MgSO4
  5. concentrationconcentrated

出典と根拠

ORDレコード
ord-7550570bd5e147f9a251ee4012531873
出典データセット
uspto-grants-1997_04
特許番号
US05616729

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