Diethyl Ether → HCID 67958514、化合物
反応式
[NH2:1][C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([O:8][CH3:9])[C:3]=1[C:10](=[O:12])[CH3:11].[CH3:13][Mg]Br.CCOCC>C1COCC1>[NH2:1][C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([O:8][CH3:9])[C:3]=1[C:10]([OH:12])([CH3:13])[CH3:11]参加物
5
反応条件
- 温度
- 0 °C
実験手順
1-(2-Amino-6-methoxyphenyl)ethanone (500 mg, 3.03 mmol) was dissolved in THF (7.5 mL) and cooled to 0° C. A 3M solution of Methyl magnesium bromide in Et2O (2.12 ml, 6.36 mmol) was added drop wise keeping the temperature below 10° C. The reaction was quenched with an aqueous saturated solution of NH4Cl (7.5 mL) keeping the temperature below 15° C. The mixture was diluted with water and ethyl acetate, two phases separated and the organic layer was washed twice with brine, dried over Na2SO4 and evaporated to dryness affording the title compound (500 mg) as light orange solid.
後処理
- customthe temperature below 10° C
- customThe reaction was quenched with an aqueous saturated solution of NH4Cl (7.5 mL)
- customthe temperature below 15° C
- additionThe mixture was diluted with water and ethyl acetate, two phases
- customseparated
- washthe organic layer was washed twice with brine
- dry with materialdried over Na2SO4
- customevaporated to dryness
出典と根拠
- ORDレコード
- ord-2649a1e0b7f742a4a1934da9c09a57b6
- 出典データセット
- uspto-grants-2016_05
- 特許番号
- US09346790B2
反応ノート
読み込み中…