Hydrochloric Acid → 2-Quinolinemethanol

HRID 52841

反応式

HRID 52841 の反応式
[N:1]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH:4]=[CH:3][C:2]=1[CH:11]=[O:12].[BH4-].[Na+].Cl>C(O)C>[OH:12][CH2:11][C:2]1[CH:3]=[CH:4][C:5]2[C:10](=[CH:9][CH:8]=[CH:7][CH:6]=2)[N:1]=1

参加物

5

反応物 3

HCID 313Hydrochloric AcidHCID 796192-QuinolinecarboxaldehydeHCID 4311764Sodium borohydride

生成物 1

HCID 731962-Quinolinemethanol収率 88%

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

A solution of 3.0 g of quinoline-2-carboxaldehyde in 100 ml of ethanol was treated with 750 mg of sodium borohydride and stirred at ambient temperature for 15 min. The resulting solution was neutralized with 1N HCl, concentrated in vacuo, and extracted three times with ethyl acetate. The combined organic layers were dried over Na2SO4 and concentrated to provide 2.65 g (88%) of the crude desired compound.

後処理

  1. concentrationconcentrated in vacuo
  2. extractionextracted three times with ethyl acetate
  3. dry with materialThe combined organic layers were dried over Na2SO4
  4. concentrationconcentrated

出典と根拠

ORDレコード
ord-1ab4b932eb7a44b190073a611411ade3
出典データセット
uspto-grants-1997_04
特許番号
US05616714

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