Trifluoroacetic acid → 3-Benzothiazol-2-yl-azetidine trifluoroacetate

HRID 528739ノート

反応式

HRID 528739 の反応式
C(OC([N:8]1[CH2:11][CH:10]([C:12]2[S:13][C:14]3[CH:20]=[CH:19][CH:18]=[CH:17][C:15]=3[N:16]=2)[CH2:9]1)=O)(C)(C)C.[C:21]([OH:27])([C:23]([F:26])([F:25])[F:24])=[O:22]>C(Cl)Cl>[F:24][C:23]([F:26])([F:25])[C:21]([OH:27])=[O:22].[S:13]1[C:14]2[CH:20]=[CH:19][CH:18]=[CH:17][C:15]=2[N:16]=[C:12]1[CH:10]1[CH2:9][NH:8][CH2:11]1

参加物

4

反応物 2

HCID 6422Trifluoroacetic acidHCID 442398183-Benzothiazol-2-yl-azetidine-1-carboxylic acid tert-butyl ester

生成物 1

HCID 674587613-Benzothiazol-2-yl-azetidine trifluoroacetate

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

To 48 mg (166 μmol) 3-benzothiazol-2-yl-azetidine-1-carboxylic acid tert-butyl ester was added 5 mL DCM and 5 mL TFA. The resulting mixture was stirred at room temperature for 30 minutes. The solvent was evaporated to give the product as the TFA salt which was used in the next step without further purification.

後処理

  1. customThe solvent was evaporated

出典と根拠

ORDレコード
ord-f3496f97b59944cf94bf5c815d221f4b
出典データセット
uspto-grants-2016_05
特許番号
US09346816B2

反応ノート

読み込み中…