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Potassium Carbonate → tert-Butyl 3-ethynylpyrrolidine-1-carboxylate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Potassium Carbonate | HCID 11430 | — |
| 反応物 | (+-)-1-(tert-Butoxycarbonyl)pyrrolidine-3-carboxaldehyde | HCID 4692112 | — |
| 反応物 | (1Z)-1-diazo-1-diethoxyphosphorylpropan-2-one | HCID 136104435 | — |
| 溶媒 | Methanol | HCID 887 | — |
| 生成物 | tert-Butyl 3-ethynylpyrrolidine-1-carboxylate | HCID 54012212 | — |
反応手順
To 1.23 g (6.17 mmol) 3-Formyl-pyrrolidine-1-carboxylic acid tert-butyl ester in 30 mL dry MeOH was added at room temperature 1.42 g (7.41 mmol) (1-Diazo-2-oxo-propyl)-phosphonic acid diethyl ester and 1.71 g (12.4 mmol) K2CO3 and stirring was continued for 2 h. 10 g of silica gel was added to the reaction mixture, stirring continued for 20 min and then filtered. After evaporation of the solvent the residue was purified by column chromatography (silica, cyclohexane/EtOAc 1:1).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US09346816B2 |
| 出典データセット | uspto-grants-2016_05 |
| ORD ID | ord-b66536a3de4d4670aac403b60817204e |
| 出典メモ | uspto-grants-2016_05 |