反应详情

To 1.23 g (6.17 mmol) 3-Formyl-pyrrolidine-1-carboxylic acid tert-butyl ester in 30 mL dry MeOH was added at room temperature 1.42 g (7.41 mmol) (1-Diazo-2-oxo-propyl)-phosphonic acid diethyl ester and 1.71 g (12.4 mmol) K2CO3 and stirring was continued for 2 h. 10 g of silica gel was added to the reaction mixture, stirring continued for 20 min and then filtered. After evaporation of the solvent the residue was purified by column chromatography (silica, cyclohexane/EtOAc 1:1).

1. addition10 g of silica gel was added to the reaction mixture
2. stirringstirring
3. waitcontinued for 20 min
4. filtrationfiltered
5. customAfter evaporation of the solvent the residue
6. customwas purified by column chromatography (silica, cyclohexane/EtOAc 1:1)