Trifluoroacetic acid → 3-Ethynyl-pyrrolidinium trifluoro-acetate

HRID 528776ノート

反応式

HRID 528776 の反応式
C(OC([N:8]1[CH2:12][CH2:11][CH:10]([C:13]#[CH:14])[CH2:9]1)=O)(C)(C)C.[C:15]([OH:21])([C:17]([F:20])([F:19])[F:18])=[O:16]>C(Cl)Cl>[F:18][C:17]([F:20])([F:19])[C:15]([O-:21])=[O:16].[C:13]([CH:10]1[CH2:11][CH2:12][NH2+:8][CH2:9]1)#[CH:14]

参加物

4

反応物 2

HCID 6422Trifluoroacetic acidHCID 54012212tert-Butyl 3-ethynylpyrrolidine-1-carboxylate

生成物 1

HCID 866671763-Ethynyl-pyrrolidinium trifluoro-acetate

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

To 0.85 g (4.35 mmol) 3-Ethynyl-pyrrolidine-1-carboxylic acid tert-butyl ester in 30 mL DCM was added 2 mL (26.0 mmol) TFA and stirring was continued at room temperature for 3 h. The solvents were evaporated and the residue was used for the next step without further purification.

後処理

  1. customThe solvents were evaporated
  2. customthe residue was used for the next step without further purification

出典と根拠

ORDレコード
ord-c1eb13ada4284922a86903b907fe8526
出典データセット
uspto-grants-2016_05
特許番号
US09346816B2

反応ノート

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