1-ethyl-2,3-dihydro-1H-indole-5-sulfonamide → 1-(3,4-Dichlorobenzyl)indoline-5-sulfonamide

HRID 528826

反応式

HRID 528826 の反応式
C(N1C2C(=CC(S(N)(=O)=O)=CC=2)CC1)C.[Cl:16][C:17]1[CH:18]=[C:19]([CH:35]=[CH:36][C:37]=1[Cl:38])[C:20]([N:22]1[C:30]2[C:25](=[CH:26][C:27]([S:31]([NH2:34])(=[O:33])=[O:32])=[CH:28][CH:29]=2)[CH2:24][CH2:23]1)=O>>[Cl:16][C:17]1[CH:18]=[C:19]([CH:35]=[CH:36][C:37]=1[Cl:38])[CH2:20][N:22]1[C:30]2[C:25](=[CH:26][C:27]([S:31]([NH2:34])(=[O:33])=[O:32])=[CH:28][CH:29]=2)[CH2:24][CH2:23]1

参加物

3

反応物 2

HCID 321037261-ethyl-2,3-dihydro-1H-indole-5-sulfonamideHCID 710607641-(3,4-Dichlorobenzoyl)indoline-5-sulfonamide2 回

生成物 1

HCID 349130801-(3,4-Dichlorobenzyl)indoline-5-sulfonamide収率 61%

実験手順

Following a procedure analogous to that for the synthesis of Intermediate 53, 1-(3,4-dichlorobenzoyl)indoline-5-sulfonamide (Intermediate 58, 70 mg, 0.19 mmol) was converted to the title compound (41 mg, 61%) after purification using preparative HPLC. 1H NMR (DMSO-d6) δ 7.63-7.58 (m, 2H), 7.48-7.43 (m, 2H), 7.31 (dd, J=8.3, 2.1 Hz, 1H), 6.91 (s, 2H), 6.60 (d, J=8.1 Hz, 1H), 4.41 (s, 2H), 3.46 (t, J=8.7 Hz, 2H), 3.03-2.98 (m, 2H); MS(ESI+) m/z 356.9 (M+H)+.

出典と根拠

ORDレコード
ord-c5217f16d8134778a2fd4f3e5283e500
出典データセット
uspto-grants-2016_05
特許番号
US09346795B2

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