反応式
[CH:1]([O:4][C:5]1[CH:6]=[C:7]([CH2:11][NH2:12])[CH:8]=[CH:9][CH:10]=1)([CH3:3])[CH3:2].[CH:13](=O)[CH2:14][CH2:15][CH3:16]>>[CH:1]([O:4][C:5]1[CH:6]=[C:7]([CH:8]=[CH:9][CH:10]=1)[CH2:11][NH:12][CH2:13][CH2:14][CH2:15][CH3:16])([CH3:3])[CH3:2]参加物
3
実験手順
Following a procedure analogous to that for the synthesis of Example 106, (3-isopropoxyphenyl)methanamine (Matrix, 200 mg, 1.21 mmol) and butyraldehyde (110 μL, 1.21 mmol) were converted to the title compound (43 mg, 16%). 1H NMR (CDCl3) δ 7.29-7.17 (m, 1H), 6.99-6.74 (m, 3H), 4.57 (td, J=6.1, 12.1 Hz, 1H), 3.80 (s, 2H), 2.65 (t, J=7.3 Hz, 2H), 1.63-1.50 (m, 2H), 1.40-1.24 (m, 8H), 0.90 (t, J=7.3 Hz, 3H); MS (ESI+) m/z 222.2 (M+H)+.
出典と根拠
- ORDレコード
- ord-3f508e031e714908a062273ee0ee9b69
- 出典データセット
- uspto-grants-2016_05
- 特許番号
- US09346795B2
関連ノート
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