ethyl 4-chloro-5-methyl-1H-pyrazole-3-carboxylate → N,N-dibutyl-4-chloro-5-methyl-1H-pyrazol-3-amine

HRID 528951

反応式

HRID 528951 の反応式
[Cl:1][C:2]1[C:3]([C:8](OCC)=O)=[N:4][NH:5][C:6]=1C.[CH2:13]([N:17](CCCC)[C:18]1[CH:22]=[C:21]([CH3:23])NN=1)[CH2:14][CH2:15][CH3:16]>>[CH2:13]([N:17]([CH2:18][CH2:22][CH2:21][CH3:23])[C:6]1[C:2]([Cl:1])=[C:3]([CH3:8])[NH:4][N:5]=1)[CH2:14][CH2:15][CH3:16]

参加物

3

反応物 2

HCID 604759ethyl 4-chloro-5-methyl-1H-pyrazole-3-carboxylateHCID 71062304N,N-dibutyl-5-methyl-1H-pyrazol-3-amine

生成物 1

HCID 71062210N,N-dibutyl-4-chloro-5-methyl-1H-pyrazol-3-amine収率 61%

実験手順

Following a procedure analogous to that for the synthesis of Intermediate 1A, N,N-dibutyl-5-methyl-1H-pyrazol-3-amine (419 mg, 2.00 mmol) was converted to the title compound (297 mg, 61%). 1H NMR (CDCl3) δ 3.26-3.17 (m, 4H), 2.19 (s, 3H), 1.57-1.44 (m, 4H), 1.32 (qd, J=15.0, 7.3 Hz, 4H), 0.91 (t, J=7.4 Hz, 6H); MS(ESI+) m/z 243.9 (M+H)+.

出典と根拠

ORDレコード
ord-8c1c051578e542baa38bd518e8ff9a64
出典データセット
uspto-grants-2016_05
特許番号
US09346795B2

関連ノート

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