Methanol → L-cysteic acid methyl ester hydrochloride

HRID 529206

反応式

HRID 529206 の反応式
[NH2:1][C@H:2]([C:8]([OH:10])=[O:9])[CH2:3][S:4](=[O:7])([OH:6])=[O:5].S(Cl)([Cl:13])=O.[CH3:15]O>>[ClH:13].[CH3:15][O:9][C:8](=[O:10])[C@H:2]([CH2:3][S:4](=[O:6])([OH:7])=[O:5])[NH2:1]

参加物

4

反応物 3

HCID 887MethanolHCID 24386Thionyl ChlorideHCID 72886L-Cysteic acid

生成物 1

HCID 86673321L-cysteic acid methyl ester hydrochloride収率 75%

実験手順

L-Cysteic acid (300 mg, 1.77 mmol) was dissolved in methanol (12 mL), and thionyl chloride (2.5 mL, 34 mmol) was slowly added dropwise at 0° C. After stirring at room temperature overnight, the reaction mixture was concentrated under reduced pressure, and the obtained residue was suspended in diisopropyl ether. The suspension was filtered to give the title compound as white crystals (291 mg, 1.33 mmol, 75%).

後処理

  1. concentrationthe reaction mixture was concentrated under reduced pressure
  2. filtrationThe suspension was filtered

出典と根拠

ORDレコード
ord-64dd1648db964d919baf6826f2235f8b
出典データセット
uspto-grants-2016_05
特許番号
US09346821B2

関連ノート

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