Hydrochloric Acid → N-allyl-L-aspartic acid di-tert-butyl ester hydrochloride

HRID 529208ノート

反応式

HRID 529208 の反応式
[C:1]([O:5][C:6](=[O:20])[C@H:7]([CH2:12][C:13]([O:15][C:16]([CH3:19])([CH3:18])[CH3:17])=[O:14])[NH:8][CH2:9][CH:10]=[CH2:11])([CH3:4])([CH3:3])[CH3:2].O.[ClH:22]>C(#N)C>[ClH:22].[C:1]([O:5][C:6](=[O:20])[C@H:7]([CH2:12][C:13]([O:15][C:16]([CH3:19])([CH3:18])[CH3:17])=[O:14])[NH:8][CH2:9][CH:10]=[CH2:11])([CH3:4])([CH3:2])[CH3:3]

参加物

5

反応物 3

HCID 313Hydrochloric AcidHCID 962WaterHCID 86673330N-allyl-L-aspartic acid di-tert-butyl ester

生成物 1

HCID 86673331N-allyl-L-aspartic acid di-tert-butyl ester hydrochloride収率 95%

試薬・触媒・溶媒 1

HCID 6342Acetonitrile溶媒

実験手順

To the compound (0.50 g, 1.8 mmol) obtained in step 1 were added water (17 mL) and 1N hydrochloric acid (1.8 mL, 1.8 mmol). Acetonitrile (10 ml) was added to dissolve the mixture, and the solution was concentrated under reduced pressure, and lyophilized to give the title compound (0.54 g, 1.7 mmol, 95%).

後処理

  1. dissolutionto dissolve the mixture
  2. concentrationthe solution was concentrated under reduced pressure

出典と根拠

ORDレコード
ord-9c7fe5a3e3b24d4d85ca86f0be782854
出典データセット
uspto-grants-2016_05
特許番号
US09346821B2

反応ノート

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