Chlorosuccinimide → 2-(5-(3-Chloropyrazolo[1,5-a]pyridin-2-yl)pyridin-3-yl)propan-2-ol

HRID 530020ノート

反応式

HRID 530020 の反応式
[N:1]1[N:5]2[CH:6]=[CH:7][CH:8]=[CH:9][C:4]2=[CH:3][C:2]=1[C:10]1[CH:11]=[C:12]([C:16]([OH:19])([CH3:18])[CH3:17])[CH:13]=[N:14][CH:15]=1.[Cl:20]N1C(=O)CCC1=O>C(#N)C>[Cl:20][C:3]1[C:2]([C:10]2[CH:11]=[C:12]([C:16]([OH:19])([CH3:17])[CH3:18])[CH:13]=[N:14][CH:15]=2)=[N:1][N:5]2[CH:6]=[CH:7][CH:8]=[CH:9][C:4]=12

参加物

4

反応物 2

HCID 31398ChlorosuccinimideHCID 894632872-(5-(Pyrazolo[1,5-a]pyridin-2-yl)pyridin-3-yl)propan-2-ol

生成物 1

HCID 894716412-(5-(3-Chloropyrazolo[1,5-a]pyridin-2-yl)pyridin-3-yl)propan-2-ol

試薬・触媒・溶媒 1

HCID 6342Acetonitrile溶媒

実験手順

A solution of the title compound from Example 2 Step A (0.099 g, 0.391 mmol) and N-chlorosuccinimide (0.063 g, 0.469 mmol) in acetonitrile (1.95 ml) was stirred at room temperature for 2 hours. The reaction was then concentrated under reduced pressure, diluted with dichloromethane, washed with saturated aqueous sodium chloride solution, dried over MgSO4, filtered and concentrated under reduced pressure.

後処理

  1. concentrationThe reaction was then concentrated under reduced pressure
  2. additiondiluted with dichloromethane
  3. washwashed with saturated aqueous sodium chloride solution
  4. dry with materialdried over MgSO4
  5. filtrationfiltered
  6. concentrationconcentrated under reduced pressure

出典と根拠

ORDレコード
ord-f562f1dfda3e47aa9c76622bbff42f6c
出典データセット
uspto-grants-2016_05
特許番号
US09351973B2

反応ノート

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