4,4'-Dimethoxybenzil → 4,4'-Dihydroxybenzil

HRID 530417

反応式

HRID 530417 の反応式
C[O:2][C:3]1[CH:8]=[CH:7][C:6]([C:9]([C:11]([C:13]2[CH:18]=[CH:17][C:16]([O:19]C)=[CH:15][CH:14]=2)=[O:12])=[O:10])=[CH:5][CH:4]=1>Br.CC([O-])=O>[OH:2][C:3]1[CH:4]=[CH:5][C:6]([C:9](=[O:10])[C:11]([C:13]2[CH:18]=[CH:17][C:16]([OH:19])=[CH:15][CH:14]=2)=[O:12])=[CH:7][CH:8]=1

参加物

4

反応物 1

HCID 710434,4'-Dimethoxybenzil

生成物 1

HCID 4582044,4'-Dihydroxybenzil収率 105.9%

試薬・触媒・溶媒 2

HCID 175Acetate溶媒HCID 260Hydrogen Bromide溶媒

実験手順

4,4′-dimethoxybenzil (2.0 g, 7.41 mmol) was dissolved in 30 mL of hydrogen bromide and 10 mL of acetic acid glacial. The reaction was stirred at reflux temperature overnight. The mixture was extracted with ethyl acetate and the organic phase was washed with water, dried over sodium sulphate. Concentration under vaccum gave the title compound as a yellow solid (1.9 g, quantitative).

後処理

  1. temperatureat reflux temperature overnight
  2. extractionThe mixture was extracted with ethyl acetate
  3. washthe organic phase was washed with water
  4. dry with materialdried over sodium sulphate
  5. concentrationConcentration under vaccum

出典と根拠

ORDレコード
ord-4a62e416177a4f4ebd82c7f82b8a06e7
出典データセット
uspto-grants-2016_05
特許番号
US09353089B2

関連ノート

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