Methyl iodide → 1-Bromo-3-methoxy-5-methylbenzene

HRID 530424

反応式

HRID 530424 の反応式
[Br:1][C:2]1[CH:3]=[C:4]([OH:9])[CH:5]=[C:6]([CH3:8])[CH:7]=1.[C:10]([O-])([O-])=O.[K+].[K+].CI>CC(C)=O>[Br:1][C:2]1[CH:7]=[C:6]([CH3:8])[CH:5]=[C:4]([O:9][CH3:10])[CH:3]=1

参加物

5

反応物 3

HCID 6328Methyl iodideHCID 11430Potassium CarbonateHCID 126484093-Bromo-5-methylphenol

生成物 1

HCID 106795541-Bromo-3-methoxy-5-methylbenzene

試薬・触媒・溶媒 1

HCID 180Acetone溶媒

反応条件

温度
40 °C

実験手順

To a mixture of 3-bromo-5-methyl-phenol (185 g; 0.940 mol) and K2CO3 (437 g, 3.17 mol) in acetone (2 L) is added MeI (424 g, 2.99 mol). The mixture is stirred at 40° C. for 16 h. The mixture is cooled to ambient temperature, filtered, and concentrated under reduced pressure. After filtration, the mixture is purified by flash silica gel chromatography to afford 1-Bromo-3-methoxy-5-methyl-benzene, D-4-1 (189 g, quant. yield) as a light yellow oil.

後処理

  1. temperatureThe mixture is cooled to ambient temperature
  2. filtrationfiltered
  3. concentrationconcentrated under reduced pressure
  4. filtrationAfter filtration
  5. customthe mixture is purified by flash silica gel chromatography

出典と根拠

ORDレコード
ord-f1abf1cb0fbf45569dbaa2de7aab9ac4
出典データセット
uspto-grants-2016_05
特許番号
US09353090B2

関連ノート

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