反応式
O.Cl.[NH:3]1[CH2:8][CH2:7][C:6](=[O:9])[CH2:5][CH2:4]1.[CH3:10][O:11][CH2:12][CH2:13]Br.C([O-])([O-])=O.[K+].[K+]>CC#N>[CH3:10][O:11][CH2:12][CH2:13][N:3]1[CH2:8][CH2:7][C:6](=[O:9])[CH2:5][CH2:4]1参加物
5
反応条件
- 温度
- 75 °C
実験手順
4-Piperidone hydrochloride monohydrate (1.00 g, 6.50 mmol), 2-bromoethyl methyl ether (1.00 g, 7.20 mmol) and K2CO3 (1.80 g, 13.0 mmol) were dissolved in MeCN (20 mL) and the reaction mixture was stirred at 75° C. for 6 h. The reaction mixture was filtered and the solvents removed in vacuo. The residue was dissolved in DCM (30 mL), stirred with isocyanate resin for 2 h, dried (MgSO4) and concentrated in vacuo to give the crude title compound (180 mg, 18%) as a colourless gum.
後処理
- filtrationThe reaction mixture was filtered
- customthe solvents removed in vacuo
- dissolutionThe residue was dissolved in DCM (30 mL)
- stirringstirred with isocyanate resin for 2 h
- dry with materialdried (MgSO4)
- concentrationconcentrated in vacuo
出典と根拠
- ORDレコード
- ord-703300dc4a604252b4bcc5646298dad9
- 出典データセット
- uspto-grants-2016_05
- 特許番号
- US09353086B2
関連ノート
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