ethyl (2S*,3R*)-2-(dibenzylamino)-3-hydroxy-pentanoate → ethyl (2S*,3R*)-2-amino-3-hydroxy-pentanoate

HRID 530551ノート

反応式

HRID 530551 の反応式
C([N:8](CC1C=CC=CC=1)[C@@H:9]([C@H:15]([OH:18])[CH2:16][CH3:17])[C:10]([O:12][CH2:13][CH3:14])=[O:11])C1C=CC=CC=1>CCO.[Pd]>[NH2:8][C@@H:9]([C@H:15]([OH:18])[CH2:16][CH3:17])[C:10]([O:12][CH2:13][CH3:14])=[O:11]

参加物

4

反応物 1

HCID 86699993ethyl (2S*,3R*)-2-(dibenzylamino)-3-hydroxy-pentanoate

生成物 1

HCID 58287050ethyl (2S*,3R*)-2-amino-3-hydroxy-pentanoate

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 702Ethanol溶媒

実験手順

In a pear flask, at rt, ethyl (2S*,3R*)-2-(dibenzylamino)-3-hydroxy-pentanoate (0.165 g, 0.48 mmol) was dissolved in EtOH (12 mL) and passed through the H-Cube® hydrogenator flow reactor, using 10% Pd/C as catalyst [flow:1.0 mL/min; P=1.0 bar, T=70° C.]. After evaporation of the solvent, the title compound was obtained as yellowish oil and used without further purification in the following step. MS (ESI) m/z: 162 [M−H]+.

後処理

  1. custom[flow:1.0 mL/min; P=1.0 bar, T=70° C.]
  2. customAfter evaporation of the solvent

出典と根拠

ORDレコード
ord-bd4bb104d3d24c4a875464214ebe46ba
出典データセット
uspto-grants-2016_05
特許番号
US09353075B2

反応ノート

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