Lawesson's reagent → HCID 86669113、化合物
反応式
[Cl:1][C:2]1[N:7]=[C:6]([C:8]([NH2:10])=O)[CH:5]=[C:4]([O:11][CH3:12])[CH:3]=1.COC1C=CC(P2(SP(C3C=CC(OC)=CC=3)(=S)S2)=[S:22])=CC=1>C1COCC1>[Cl:1][C:2]1[N:7]=[C:6]([C:8](=[S:22])[NH2:10])[CH:5]=[C:4]([O:11][CH3:12])[CH:3]=1参加物
4
反応条件
- 温度
- 90 °C
実験手順
To a solution of compound 18 (9 mmol) in THF (30 mL) was added Lawesson reagent (5.4 mmol). The reaction mixture was stirred at 90° C. for 2 hrs. After cooling at room temperature, the solution was concentrated under reduced pressure and the residue was triturated in DCM to give compound 19 as a yellow solid in 71% yield. MS (ESI, EI+): m/z=203 (MH+).
後処理
- temperatureAfter cooling at room temperature
- concentrationthe solution was concentrated under reduced pressure
- customthe residue was triturated in DCM
出典と根拠
- ORDレコード
- ord-2e60ccfb90b14f63ab1cea2b4c955993
- 出典データセット
- uspto-grants-2016_05
- 特許番号
- US09353100B2
反応ノート
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