Water → (1,3-dimethyl-1H-pyrazol-4-yl)methanamine
反応式
Cl.Cl[C:3]1[N:7]([CH3:8])[N:6]=[C:5]([CH3:9])[C:4]=1[CH2:10][NH2:11].[H-].[H-].[H-].[H-].[Li+].[Al+3].O>C1COCC1>[CH3:8][N:7]1[CH:3]=[C:4]([CH2:10][NH2:11])[C:5]([CH3:9])=[N:6]1参加物
5
実験手順
To a solution of compound 4 (120 mg, 0.61 mmol) in THF (5 mL) was added LAH (43 mg, 3.78 mmol). The resulting mixture was stirred at room temperature overnight. Water was added and the resulting mixture was filtered. Organic layer was separated and then concentrated in vacuum to give a white solid (crude product). LCMS (ESI) m/z=126 (M+H)+.
後処理
- filtrationthe resulting mixture was filtered
- customOrganic layer was separated
- concentrationconcentrated in vacuum
- customto give a white solid (crude product)
出典と根拠
- ORDレコード
- ord-a602945824aa427dbe9dfe180f482602
- 出典データセット
- uspto-grants-2016_05
- 特許番号
- US09353104B2
反応ノート
読み込み中…