Sodium borohydride → (5-Chloro-6-methylpyridin-2-YL)methanamine

HRID 530802ノート

反応式

HRID 530802 の反応式
[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([C:9]#[N:10])=[N:6][C:7]=1[CH3:8].[BH4-].[Na+]>CO.O>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([CH2:9][NH2:10])=[N:6][C:7]=1[CH3:8]

参加物

5

反応物 2

HCID 4311764Sodium borohydrideHCID 573365975-Chloro-6-methylpyridine-2-carbonitrile

生成物 1

HCID 72214042(5-Chloro-6-methylpyridin-2-YL)methanamine

試薬・触媒・溶媒 2

HCID 887Methanol溶媒2 回HCID 962Water溶媒

実験手順

To a mixture of 5-chloro-6-methylpicolinonitrile (3) (200 mg, 1.31 mmol) in MeOH (10 mL) was added NaBH4 (150 mg, 3.94 mmol), CoCl2 (5 mg) at room temperature. After 30 min, the mixture was filtered and purified by reverse phase chromatography (X bridge Prep C18OBD, 40-60% MeOH in water with 10 mmol NH4HCO3 modifier) to afford the compound as an oil.

後処理

  1. filtrationthe mixture was filtered

出典と根拠

ORDレコード
ord-04b217567ed54c7c9f8e2180148604cc
出典データセット
uspto-grants-2016_05
特許番号
US09353104B2

反応ノート

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