Hydrochloric Acid → 5,6-Dimethyl-2-pyridinemethanamine

HRID 530807ノート

反応式

HRID 530807 の反応式
[CH3:1][C:2]1[CH:3]=[CH:4][C:5]([C:9]#[N:10])=[N:6][C:7]=1[CH3:8].Cl.[H][H]>CO.[Pd]>[CH3:1][C:2]1[CH:3]=[CH:4][C:5]([CH2:9][NH2:10])=[N:6][C:7]=1[CH3:8]

参加物

6

反応物 3

HCID 313Hydrochloric AcidHCID 224176635,6-Dimethylpyridine-2-carbonitrileHCID 178418361HCID 178418361、化合物

生成物 1

HCID 450795455,6-Dimethyl-2-pyridinemethanamine

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 887Methanol溶媒

実験手順

To a solution of compound 3 in Scheme 4-3 (58 mg, 0.44 mmol) in MeOH (5 mL) and 6N HCl (1 mL) was added Pd/C (10 mg) at room temperature, the mixture was filled with hydrogen for three times and stirred overnight. The reaction mixture was filtered through celite and washed with MeOH and the filtrate was concentrated. The residue was concentrated to give compound 4 as a dark brown solid.

後処理

  1. filtrationThe reaction mixture was filtered through celite
  2. washwashed with MeOH
  3. concentrationthe filtrate was concentrated
  4. concentrationThe residue was concentrated

出典と根拠

ORDレコード
ord-00fbc19929f245a6a70e99e326c1c017
出典データセット
uspto-grants-2016_05
特許番号
US09353104B2

反応ノート

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