Ethanol → (3-ethyl-1-methyl-1H-pyrazol-5-yl)methanol
反応式
[CH2:1]([C:3]1[CH:7]=[C:6]([C:8](OCC)=[O:9])[N:5]([CH3:13])[N:4]=1)[CH3:2].[H-].[Al+3].[Li+].[H-].[H-].[H-].C(O)C.[Cl-].[NH4+]>C1COCC1>[CH2:1]([C:3]1[CH:7]=[C:6]([CH2:8][OH:9])[N:5]([CH3:13])[N:4]=1)[CH3:2]参加物
6
実験手順
To a solution of compound 3 (2 g, 0.01 mol) in THF (20 mL) was added lithium aluminum hydride (0.63 g, 0.02 mol) at 0° C. and the mixture was stirred at room temperature for 30 min. Ethanol (10 mL) and saturated aqueous ammonium chloride solution (2.0 mL) were added to the reaction mixture. The precipitated insoluble material was filtered off, and the filtrate was concentrated under reduced pressure. The residue was subjected to silica gel chromatography (ethyl acetate:hexane=1:1) to give the title compound as a colorless oil.
後処理
- filtrationThe precipitated insoluble material was filtered off
- concentrationthe filtrate was concentrated under reduced pressure
出典と根拠
- ORDレコード
- ord-22a6b5b04f6b4770965b41f0026b769a
- 出典データセット
- uspto-grants-2016_05
- 特許番号
- US09353104B2
反応ノート
読み込み中…